Wrinkles
Lines and creases in skin caused by aging, sun exposure, and repetitive facial movement.
Wrinkles are folds, ridges or creases in the skin that appear as a natural part of aging. They deepen with cumulative sun exposure, repetitive facial expressions, loss of collagen and elastin, and declining skin hydration. The DermaGenome Knowledge Graph connects wrinkles to their causes, treatments, key ingredients, devices, and research.
Overview
Wrinkles form when the dermis loses collagen and elastin support, and the epidermis thins. Static wrinkles result from gravity and loss of tissue; dynamic wrinkles from repeated muscle contraction.
Causes
UV radiation (photoaging), intrinsic aging, oxidative stress, glycation, repetitive facial movement, smoking, dehydration, and hormonal changes.
Treatments
Topical retinoids, peptides, vitamin C, hyaluronic acid; in-office procedures: retinol, microneedling, laser resurfacing, and LED therapy.
Connected Concepts
Ingredients
Causes